Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients
| Autor: | Luc J. C. van Loon, Joan M. G. Senden, Bregje J. W. Thomassen, Will K. W. H. Wodzig, Kristof Vanschoonbeek |
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| Přispěvatelé: | Humane Biologie, MUMC+: DA CDL Algemeen (9), RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| Rok vydání: | 2006 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Cinnamomum zeylanicum medicine.medical_treatment Medicine (miscellaneous) Blood lipids Type 2 diabetes Body Mass Index Placebos Insulin resistance Double-Blind Method Internal medicine Diabetes mellitus medicine Humans Insulin Glycemic Glycated Hemoglobin Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test business.industry Fasting Glucose Tolerance Test Middle Aged medicine.disease Lipids Postmenopause Endocrinology Diabetes Mellitus Type 2 Dietary Supplements Female Insulin Resistance Lipid profile business Energy Intake |
| Zdroj: | Journal of Nutrition, 136(4), 977-980. Oxford University Press |
| ISSN: | 0022-3166 |
| Popis: | In vitro and in vivo animal studies have reported strong insulin-like or insulin-potentiating effects after cinnamon administration. Recently, a human intervention study showed that cinnamon supplementation (1 g/d) strongly reduced fasting blood glucose concentration (30%) and improved the blood lipid profile in patients with type 2 diabetes. The objective of this study was to investigate the effects of cinnamon supplementation on insulin sensitivity and/or glucose tolerance and blood lipid profile in patients with type 2 diabetes. Therefore, a total of 25 postmenopausal patients with type 2 diabetes (aged 62.9 +/- 1.5 y, BMI 30.4 +/- 0.9 kg/m(2)) participated in a 6-wk intervention during which they were supplemented with either cinnamon (Cinnamomum cassia, 1.5 g/d) or a placebo. Before and after 2 and 6 wk of supplementation, arterialized blood samples were obtained and oral glucose tolerance tests were performed. Blood lipid profiles and multiple indices of whole-body insulin sensitivity were determined. There were no time x treatment interactions for whole-body insulin sensitivity or oral glucose tolerance. The blood lipid profile of fasting subjects did not change after cinnamon supplementation. We conclude that cinnamon supplementation (1.5 g/d) does not improve whole-body insulin sensitivity or oral glucose tolerance and does not modulate blood lipid profile in postmenopausal patients with type 2 diabetes. More research on the proposed health benefits of cinnamon supplementation is warranted before health claims should be made. AD - Department of Clinical Chemistry, Academic Hospital Maastricht, The Netherlands. |
| Databáze: | OpenAIRE |
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