Glucocorticoidal Regulation of Pituitary Vasopressin Content in Rats
| Autor: | Masaru Shoji, Minoru Yasujima, Masahiro Ohta, Tokihisa Kimura, Takefumi Mori, Kozo Ota, Takayuki Sahata |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
endocrine system Vasopressin medicine.medical_specialty Physiology Hypothalamus Radioimmunoassay Dexamethasone Rats Sprague-Dawley Basal (phylogenetics) chemistry.chemical_compound Hormone Antagonists Receptors Glucocorticoid Internal medicine Internal Medicine medicine Animals Secretion RNA Messenger Glucocorticoids Messenger RNA urogenital system Chemistry Antiglucocorticoid Blotting Northern Actins Rats Arginine Vasopressin Mifepristone Endocrinology nervous system Pituitary Gland Cardiology and Cardiovascular Medicine hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Hypertension Research. 22:39-42 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1291/hypres.22.39 |
| Popis: | Although glucocorticoids are known to attenuate vasopressin (AVP) secretion, it is still controversial whether glucocorticoids act on the hypothalamo-neurohypophysial system. We report here glucocorticoidal regulation of pituitary AVP content, which is a specific indicator for the system. The hypothalamic AVP mRNA content and the pituitary AVP content were measured in rats given dexamethasone (2 mg/kg, 2 times over the course of 5 d) or the glucocorticoid receptor antagonist RU-38486 (20mg/kg, 3 times over the course of 3 d) during euhydration or dehydration. In dexamethasone-treated rats, both the hypothalamic AVP mRNA content and pituitary AVP content decreased after dehydration. In contrast, in the RU-38486 group the hypothalamic AVP mRNA content and pituitary AVP content increased in both euhydrated and dehydrated rats. These results suggest that glucocorticoids may act on hypothalamo-neurohypophysial vasopressinergic system and attenuate its activity under both basal and dehydrated states. (Hypertens Res 1999; 22: 39-42) |
| Databáze: | OpenAIRE |
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