Antibodies to Pf155/RESA and circumsporozoite protein of Plasmodium falciparum in paired maternal-cord sera from Nigeria
| Autor: | Hedvig Perlmann, Klavs Berzins, Peter Perlmann, L.S. Salimonu, E. A. Achidi, Michael C. Asuzu |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Cord Adolescent Immunology Plasmodium falciparum Protozoan Proteins Antibodies Protozoan Antigens Protozoan Enzyme-Linked Immunosorbent Assay Immunofluorescence Parasitemia Antigen Pregnancy parasitic diseases medicine Animals Humans Malaria Falciparum Maternal-Fetal Exchange medicine.diagnostic_test biology Infant Newborn biology.organism_classification medicine.disease Fetal Blood Virology Circumsporozoite protein Parity Immunoglobulin M Cord blood Immunoglobulin G Antigens Surface biology.protein Parasitology Female Antibody Immunity Maternally-Acquired Malaria |
| Zdroj: | Parasite immunology. 17(10) |
| ISSN: | 0141-9838 |
| Popis: | Summary Paired maternal-cord serum samples were analysed for antibodies to the P/155/RESA and circumsporozoite protein (CSP) antigens of Plasmodium falciparum. Malaria parasites were found in 2–6% (3/117) of cord blood and 22–4% (26/116) of maternal samples. Immunofluorescence assays detected P. falciparum-specific IgG antibodies in all paired samples while P. falciparum-specific IgM was detected in 5–8% (7/121) of cord samples. The positivity rates for antibodies to Pfl55/ RESA and (NANP)6 but not (EENV)6, a C-terminal repeat sequence of Pf155/REAS, were significantly higher in maternal as compared with cord samples. Seropositivity rates to Pf155/RESA and (EENV)6 were not related to maternal parity group while positivity rates to the (NANP)6 peptide were higher in primiparae and multi-par ae of 4 parity. These data confirm the transplacental transfer of P. falciparum-Specific antibodies and the higher incidence of malaria parasitaemia in primiparae. The presence of P. falciparum-.specific IgM in some cord samples suggests intrauterine sensitization of the foetus to malarial antigens. |
| Databáze: | OpenAIRE |
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