Experimental study on effect of cigarette smoke condensate on bronchial mucosa
| Autor: | T. Hirose, Francis D. Speer, S. A. Thompson, Edward Ernest Rockey, K. J. Ahn |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
Pathology
medicine.medical_specialty Invasive carcinoma Mucous Membrane medicine.diagnostic_test business.industry Carcinoma in situ Smoking Bronchial mucosa Bronchi General Medicine Hyperplasia medicine.disease Smoke Biopsy Tobacco medicine Carcinoma Papilloma Cigarette smoke business Pyrrolizidine Alkaloids |
| Zdroj: | JAMA. 182 |
| ISSN: | 0098-7484 |
| Popis: | A study was undertaken to determine whether or not repeated applications of cigarette smoke condensate to the bronchial mucosa would be capable of producing progressive proliferative changes, including carcinoma in situ and invasive carcinoma. One-fourth of 1 cc. of cigarette smoke condensate was applied to the mesial wall of the left primary bronchus of 130 dogs, 3 to 5 times weekly. In 25 dogs the same area was submitted to rubbing manipulations. The bronchial mucosa of 27 nontreated dogs was also examined. The changes were followed up by repeated mucosal biopsies and by autopsies. Papilloma was produced in 2, precancerous changes in 25, carcinoma in situ in 3, and invasive carcinoma in 1 of of the 130 dogs treated with cigarette smoke condensate. |
| Databáze: | OpenAIRE |
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