Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19

Autor: Giovanna Calixto Garcia Carlini, Matheus de Castro Leão, Tamires Miranda Santana, Renata de Cássia Gonçalves, Inar Alves de Castro, Mariana V. de M.B. Pimentel, Tayse Ferreira Ferreira da Silveira, Marcelo Macedo Rogero
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Docosahexaenoic Acids
Pneumonia
Viral
Phospholipid
Inflammation
Pharmacology
medicine.disease_cause
Biochemistry
Article
03 medical and health sciences
chemistry.chemical_compound
Betacoronavirus
0302 clinical medicine
SPMs
Physiology (medical)
Medicine
Humans
Hypoxia
Pandemics
Randomized Controlled Trials as Topic
business.industry
SARS-CoV-2
Anti-Inflammatory Agents
Non-Steroidal
COVID-19
EPA
Lipid signaling
Leukopenia
Disseminated Intravascular Coagulation
medicine.disease
Eicosapentaenoic acid
DHA
Oxidative Stress
030104 developmental biology
chemistry
Eicosapentaenoic Acid
Docosahexaenoic acid
Dietary Supplements
Arachidonic acid
lipids (amino acids
peptides
and proteins)
medicine.symptom
business
Cytokine storm
Coronavirus Infections
Cytokine Release Syndrome
Reactive Oxygen Species
030217 neurology & neurosurgery
Oxidative stress
Zdroj: Free Radical Biology and Medicine
Free Radical Biology & Medicine
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2020.07.005
Popis: Studies have shown that infection, excessive coagulation, cytokine storm, leukopenia, lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) patients in addition to the onset symptoms. There are still no approved drugs or vaccines. Dietary supplements could possibly improve the patient's recovery. Omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), present an anti-inflammatory effect that could ameliorate some patients need for intensive care unit (ICU) admission. EPA and DHA replace arachidonic acid (ARA) in the phospholipid membranes. When oxidized by enzymes, EPA and DHA contribute to the synthesis of less inflammatory eicosanoids and specialized pro-resolving lipid mediators (SPMs), such as resolvins, maresins and protectins. This reduces inflammation. In contrast, some studies have reported that EPA and DHA can make cell membranes more susceptible to non-enzymatic oxidation mediated by reactive oxygen species, leading to the formation of potentially toxic oxidation products and increasing the oxidative stress. Although the inflammatory resolution improved by EPA and DHA could contribute to the recovery of patients infected with SARS-CoV-2, Omega-3 fatty acids supplementation cannot be recommended before randomized and controlled trials are carried out.
Graphical abstract Image 1
Highlights • Inflammation is critical for COVID-19 patients. • Omega-3 fatty acids can decrease inflammation. • Clinical studies must consider omega-3 fatty acids as a co-therapy in COVID-19.
Databáze: OpenAIRE
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