Bioactive constituents from Flacourtia vogelii Hook.f. (Flacourtiaceae)
| Autor: | Willifred Dongmo Tekapi Tsopgni, Flaure Rosette Ehawa Essoung, Phalonne Makam Kuetche, Anatole Guy Blaise Azebaze, Mbah James Ajeck, Alain Lannang Meli, Norbert Sewald, Jean Duplex Wansi, Alain Francois Kamdem Waffo, Alain Tadjong Tcho |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Natural Product Research. :1-11 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2023.2177287 |
| Popis: | The chemical investigation of the methanolic root extract of Flacourtia vogelii led to the isolation of a new arylbenzoate derivative, vogelinal (1), together with thirteen known compounds (2–14). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound 7 exhibited the highest antioxidant potential, with RSa50of 11.80 ± 2.13 µg/mL, RSa50of 42.60 ± 6.32 µg/mL and RC50 of 51.60 ± 7.71 µg/mL for the DPPH, ABTS and FRAP assay, respectively. Compound 13 displayed weak antifungal effect with MIC value of 125 μg/mL against Candida parapsilosis. Compound 8 showed weak antibacterial effect with MIC value of 125 μg/mL, against Shigella dysenteria. The present study, conclude that this species could be a promising source of antioxidant and antibacterial constituents. |
| Databáze: | OpenAIRE |
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