Receptores moleculares que simulan agujeros oxianiónicos: reconocimiento molecular y catálisis

Autor:	Garrido González, José Javier
Přispěvatelé:	Rodríguez Morán, Joaquín, Marcos Monleón, Laura, Fuentes de Arriba, Ángel Luis
Rok vydání:	2021
Předmět:	Academic dissertations Receptores Catálisis orgánica Universidad de Salamanca (España) 2306 Química Orgánica Tesis y disertaciones académicas Tesis Doctoral
Zdroj:	GREDOS. Repositorio Institucional de la Universidad de Salamanca Universidad Pontificia Comillas ICAI-ICADE
Popis:	[EN]The general objective of this Thesis is the design and synthesis of small organic molecules which mimic the oxyanion-hole scaffold found in hydrolytic enzymes. They employ this structural motif to associate anions and electronegative groups such as carbonyls from esters and amides and reduce the activation energy of many reactions in which a negatively-charged transition state is generated. These artificial oxyanion-hole mimic will be used to associate the carboxylic acid group of amino acids in order to carry out the chiral resolution of racemic mixtures of amino acids. In addition, they will be employed to catalyse the transesterification of non-activated esters by mimicking the mechanism of natural hydrolases
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bfa3f60932658b5d786f278be23e6d http://hdl.handle.net/10366/148400 Zobrazit plný text záznamu