Urinary neutrophil gelatinase‐associated lipocalin determines short‐term mortality and type of acute kidney injury in cirrhosis

Autor: Samit S Jain, Nikhil Sonthalia, Suhas Udgirkar, Pravin Rathi, Sanjay Chandnani, Ravi Thanage, Qais Contractor
Rok vydání: 2020
Předmět:
Zdroj: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
JGH Open, Vol 4, Iss 5, Pp 970-977 (2020)
ISSN: 2397-9070
DOI: 10.1002/jgh3.12377
Popis: Background and Aim Acute kidney injury increases mortality in cirrhotic patients by four fold. This study aimed to determine the usefulness of urinary neutrophil gelatinase‐associated lipocalin (uNGAL) for differential diagnosis for acute kidney injury and for predicting short‐term mortality in cirrhotic patients. Methods We enrolled 94 patients of decompensated cirrhosis. uNGAL was measured upon hospital admission in all patients. Patients with urinary tract infection and anuria were excluded. Patients were followed for 30 days or until death. Results Ten (9%) patients had normal kidney function, 9 (11.37%) stable chronic kidney disease, 32 (29.50%) prerenal azotemia, 33 (36.37%) hepatorenal syndrome (HRS), and 10 (13.64%) intrinsic acute kidney injury (iAKI). Prerenal azotemia had lower median uNGAL values compared to HRS and iAKI (95.50 vs 465.00 vs 1217.50, P
uNGAL at baseline serves as early marker in differentiating HRS, prerenal AKI and intrinsic AKI in cirrhotics, where sr. creatinine values are not useful. Patients with higher uNGAL levels had higher transplant free mortality at 30 days
Databáze: OpenAIRE
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