Value of SSTR2A and Claudin - 1 in Differentiating Meningioma from Schwannoma and Hemangiopericytoma
| Autor: | Shady E. Anis, Mira Lotfalla, Muhammad Zain, Ahmed A. Soliman, Nora N. Kamel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Meningioma
Hemangiopericytoma Schwannoma Claudin - 1 SSTR2A 0301 basic medicine Pathology medicine.medical_specialty lcsh:Medicine 03 medical and health sciences 0302 clinical medicine Basic Science otorhinolaryngologic diseases medicine Claudin neoplasms Somatostatin receptor business.industry lcsh:R Solitary fibrous tumour General Medicine medicine.disease nervous system diseases Staining 030104 developmental biology 030220 oncology & carcinogenesis Medicine Immunohistochemistry business |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences; Vol 6, No 2 (2018): Feb 15 (OAMJMS); 248-253 Open Access Macedonian Journal of Medical Sciences; Vol 6 No 2 (2018): Feb 15 (OAMJMS); 248-253 Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences, Vol 6, Iss 2, Pp 248-253 (2018) |
| ISSN: | 1857-9655 |
| DOI: | 10.3889/oamjms.2018.062 |
| Popis: | BACKGROUND: The distinction between meningioma, schwannoma and solitary fibrous tumour/ hemangiopericytoma can be challenging in some cases. This study evaluates the expression of Somatostatin receptor 2A (SSTR2A) and Claudin-1 in these different tumours.MATERIAL AND METHODS: Thirty-five cases of meningioma, 10 cases of intracranial schwannoma and 10 cases of hemangiopericytoma were assessed. The immunohistochemical expression of SSTR2A and Claudin-1 was evaluated and scored according to the percentage of immunostained tumour cells (0: 1+, 2+ and 3). The intensity of staining was classified as weak, moderate and strong.RESULTS: Positivity for SSTR2A and Claudin-1 was encountered in 89% and 49% of meningiomas respectively. None of the schwannomas or hemangiopericytomas was positive for any of both markers. All grade I and II meningiomas were positive for SSTR2A, and only 20% of grade III showed positive staining (p < 0.05). Claudin-1 positivity was detected in 50%, 43% and 60% of grade I, II and III meningioma respectively, with significantly higher intensity in grade III (p < 0.05).CONCLUSION: SSTR2A is highly sensitive and specific for meningioma. Claudin-1 is highly specific for meningioma, with low sensitivity. The adjunctive use of both markers can be very helpful in the diagnosis of meningioma and its distinction from schwannoma and hemangiopericytoma. |
| Databáze: | OpenAIRE |
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