Blood clearance half-times in lactating and nonlactating members of a population exposed to methylmercury
| Autor: | Thomas W. Clarkson, Richard A. Doherty, Laman Amin-Zaki, Allen H. Gates, Michael R. Greenwood, Mohammed A. Majeed, Sami B. Elhassani |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Adolescent Organomercury Compounds Metabolic Clearance Rate Population Biology Biochemistry Toxicology Excretion chemistry.chemical_compound Mice Animal science Pregnancy Lactation medicine Ingestion Animals Humans education Child Methylmercury General Environmental Science education.field_of_study medicine.disease medicine.anatomical_structure chemistry Toxicity Female Hormone |
| Zdroj: | Environmental research. 16(1-3) |
| ISSN: | 0013-9351 |
| Popis: | An epidemic of methylmercury poisoning occurred in rural Iraq early in 1972 due to the ingestion of homemade bread prepared from wheat treated with a methylmercury fungicide. We report observations of the blood mercury clearance half-times of lactating women and nonlactating groups who were exposed during the epidemic. Blood clearance half-times calculated by linear regression analysis show that in lactating females, the mean half-time is 42 days and in nonlactating females and males, the mean half-time is 75 days. Experiments in mice also show such differences in whole body half-time: 5.6 days in lactating females and 9.3 days in nonlactating females. |
| Databáze: | OpenAIRE |
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