New azaphilones and tremulane sesquiterpene from endophytic Nigrospora oryzae cocultured with Irpex lacteus
| Autor: | Zhong-Tao Ding, Bang-Yan Wang, Ming Hu, Ya-Bin Yang, Zhuo-Xi Zhang, Qing-Yan Zhou, Xue-Qiong Yang, Hao Zhou |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antifungal medicine.drug_class Stereochemistry Irpex lacteus Fungus Sesquiterpene 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Ascomycota Drug Discovery medicine Benzopyrans Competitive interaction Spectral analysis Nigrospora oryzae Pharmacology Molecular Structure biology 010405 organic chemistry fungi Pigments Biological General Medicine biology.organism_classification Acetylcholinesterase Coculture Techniques Fungicides Industrial 0104 chemical sciences 030104 developmental biology chemistry Cholinesterase Inhibitors Polyporales Sesquiterpenes |
| Zdroj: | Fitoterapia. 130:26-30 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2018.07.018 |
| Popis: | Five new metabolites belonging to two backbones of pulvilloric acid-type azaphilone and tremulane sesquiterpene were obtained and their structures were determined by spectral analysis. Based on the biogenesis analysis, tremulane sesquiterpenes were obtained from Irpex lacteus by the stimulation of mixed-culture. The antifungal selectivities of metabolites produced by fungus against their co-culture fungus and common pathogens, exhibited competitive interaction of this mix-culture. The tremulane sesquiterpene conocenol B produced by I. lacteus through the induction of Nigrospora oryzae showed selectivity of anti-fungal activity against its co-culture fungus, N. oryzae, with MICs at 16 μg/mL and 128 μg/mL against I. lacteus. The fungus can metabolize these new compounds to inhibit the growth of co-culture fungus while not inhibiting its own growth. Compound 5 was active against acetylcholinesterase (AChE) with a ratio of 35% at the concentration of 50 μM. |
| Databáze: | OpenAIRE |
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