Other Approaches to the Prevention of Aspergillosis
Autor: | David C.E. Speller |
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Rok vydání: | 1986 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty Antifungal Agents Isolation (health care) Epidemiology business.industry Aspergillosis medicine.disease Disseminated aspergillosis Environmental - origin Unit (housing) Infectious Diseases Chemoprophylaxis Humans Medicine Transplant patient business Intensive care medicine Cause of death |
Zdroj: | Infection Control & Hospital Epidemiology. 7:125-127 |
ISSN: | 1559-6834 0899-823X |
Popis: | Disseminated aspergillosis in the compromised host is an important and intractable problem in Great Britain, having a general incidence, when post-mortem data are included, approaching that quoted for the United States. It emerges as a most important cause of death in units where prolonged granulocytopenia accompanies treatment.Rhame has presented a persuasive account of the environmental origin of aspergillus infection and the possibility of its control by environmental measures. This is an important issue for those involved in the planning of new units, for the use of protective isolation is under criticism as failing to provide significant benefit, and even general provision of filtered air to the unit may be beyond the budget allowed. We have to consider the minimum necessary measures to reduce the risk. Providing HEPA-filtered air to the unit may not be sufficient in itself; British heart transplant patients have died of aspergillosis (A. fumigatus), in some cases initiated soon after surgery, despite nursing in rooms with filtered ventilation (Newsom SWB, personal communication); and respiratory ventilators have been suspected as one source within such a unit. We also have to consider other approaches to the problem. Is there an endogenous element in the production of aspergillosis? Is there any prospect of successful chemoprophylaxis? |
Databáze: | OpenAIRE |
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