A systematic review for the efficacy of coenzyme Q10 in patients with chronic kidney disease
| Autor: | Xiaowen Zuo, Hong Yan, Jianjun Gao, Juan Liu, Yan Wang, Yongxing Xu, Huaping Jia, Guolei Yang, Enhong Han |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Nephrology
medicine.medical_specialty Ubiquinone Urology 030232 urology & nephrology MEDLINE 030204 cardiovascular system & hematology Carbohydrate metabolism Cochrane Library medicine.disease_cause Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Humans Medicine Renal Insufficiency Chronic Coenzyme Q10 biology business.industry C-reactive protein Vitamins medicine.disease Treatment Outcome chemistry biology.protein business Oxidative stress Kidney disease |
| Zdroj: | International Urology and Nephrology. 54:173-184 |
| ISSN: | 1573-2584 0301-1623 |
| DOI: | 10.1007/s11255-021-02838-2 |
| Popis: | The effects of coenzyme Q10 (CoQ10) supplementation in chronic kidney disease (CKD) patients remain controversial. A systematic review of current evidence was performed to systematically and comprehensively summarize the effects of CoQ10 on cardiovascular outcomes, oxidative stress, inflammation, lipid profiles, and glucose metabolism. MEDLINE, EMBASE, and the Cochrane Library database (Cochrane Central Register of Controlled Trials) were searched to identify eligible studies investigating the effects of CoQ10 supplementation on patients with CKD. Twelve independent studies (including seventeen publications) were included in this systematic review. For CKD patients, six studies reported variable cardiovascular outcomes, which yielded inconsistent results. Regarding oxidative stress and inflammation, pooled analysis showed that CoQ10 supplementation significantly reduced malonaldehyde (WMD: − 1.15 95% CI − 1.48 to − 0.81) and high-sensitivity C reactive protein levels (WMD: − 1.18 95% CI − 2.21 to − 0.15). Regarding glucose metabolism, we found that CoQ10 supplementation resulted in significant improvements in HbA1c (WMD: − 0.80; 95% CI: − 1.35 to − 0.24) and QUICKI (WMD: 0.02; 95% CI: 0.01 to 0.03). The pooled results indicated that CoQ10 supplementation had no effects on total cholesterol, or LDL-cholesterol, or on HDL-cholesterol, and triglycerides. Our systematic review demonstrated that CoQ10 supplementation might have promising effects on oxidative stress. This work provided some clues that CoQ10 supplementation might have the potential to improve inflammation levels, glucose metabolism, cardiac structure, and cardiac biomarkers. However, the effects of CoQ10 supplementation should be confirmed in larger high-quality studies. |
| Databáze: | OpenAIRE |
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