A methotrexate-associated lympholiferative disorder patient with gastrointestinal perforation
| Autor: | Tadahiro Honda, Yuko Okuda, Yukari Wakabayashi, Keitaro Fujiwara, Akihiko Gotoh, Tsubasa Watanabe, Michio Sakurai, Tomohisa Yokoyama, Tadahito Nonaka, Sei Kimura, Yasuo Aota |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Side effect Gastrointestinal Diseases medicine.drug_class Antibiotics Gastroenterology Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine immune system diseases Gastrointestinal perforation hemic and lymphatic diseases Internal medicine medicine Humans skin and connective tissue diseases Aged 030203 arthritis & rheumatology business.industry Amyloidosis medicine.disease Lymphoproliferative Disorders Lymphoma Methotrexate 030220 oncology & carcinogenesis Rheumatoid arthritis Prednisolone Female Geriatrics and Gerontology business medicine.drug |
| Zdroj: | Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 54:567-572 |
| ISSN: | 0300-9173 |
| Popis: | A 70-year-old woman was diagnosed with chronic rheumatoid arthritis and treated with methotrexate and prednisolone. She visited our hospital to determine the cause of her continuous fatigue and fever for the past three weeks. She consumed no food orally and was provided antibiotics because free air was found on computed tomography (CT). Intraperitoneal small lymphadenopathy and swelling of both adrenal glands was also found on CT, and MTX-associated lymphoproliferative disorder (MTX-LPD) was suspected. Am adrenal gland biopsy showed diffuse large B-cell lymphoma (DLBCL) associated with MTX-LPD. The causes of gastrointestinal perforation with collagen diseases have been reported to be functional gastrointestinal disorders with collagen diseases like amyloidosis, gastrointestinal infections in immunocompromised patients, and side effects of medication, such as steroids or NSAIDs and MTX. MTX-LPD is an uncommon side effect of methotrexate. To ensure its appropriate diagnosis and treatment, it is important to improve the degree of recognition of MTX-LPD, and a prompt response is needed. |
| Databáze: | OpenAIRE |
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