An echocardiography-derived calcium score as a predictor of major adverse cardiovascular events in peritoneal dialysis patients-A prospective cohort study
| Autor: | Man-Wai Lo, Yuk-Yi Wong, Kwok-Chi Lo, Siu-Ka Mak, Ho-Kwan Sin, Ping-Nam Wong, Kai-Chun Chan, Lo-Yi Ho, Shuk-Fan Chan, Wing-Tung Kwok, Andrew K.M. Wong, Kin-Yee Lo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Population Peritoneal dialysis Cohort Studies Predictive Value of Tests Internal medicine medicine Humans Myocardial infarction Prospective Studies Prospective cohort study education Stroke Dialysis Aged education.field_of_study Proportional hazards model business.industry General Medicine Middle Aged medicine.disease Nephrology Cardiovascular Diseases Echocardiography Calcium Female business Peritoneal Dialysis Mace |
| Zdroj: | Nephrology (Carlton, Vic.)REFERENCES. 27(2) |
| ISSN: | 1440-1797 |
| Popis: | Background An echocardiography-derived calcium score (ECS) has been shown to predict CV mortality in the general population but has not been utilized in the dialysis population. Methods We conducted a prospective cohort study including 125 prevalent PD patients. Two blinded and independent echocardiographers determined the ECS for each subject at baseline. The primary outcome was the three-point major adverse cardiovascular events (MACE) which is a composite outcome comprising CV Death, non-fatal myocardial infarction and non-fatal stroke. The secondary outcome was all-cause mortality. Results The mean age was 61 ± 13 years. The median follow-up duration was 40 months (range 1-50). Diabetes mellitus (DM) occurred in 76 (60.8%) of the subjects. The median duration of dialysis was 32 (IQR 16-54) months. The incidences of MACE and all-cause mortality were 13.0 per 100 patient-years and 18.3 per 100 patient-years. Multivariate Cox regression analysis identified the following 3 independent predictors of MACE: ECS (HR 1.253 / unit increase in ECS, 95% CI 1.014-1.547, p = 0.036), DM (HR 2.467, 95% CI 1.014-6.005, p = 0.047) and pre-existing CVD (HR 2.441, 95% CI 1.261-4.728, p = 0.008); and the following 2 predictors of all-cause mortality: pre-existing CVD (HR 2.156, 95% CI 1.251-3.714, p = 0.006) and serum albumin (HR 0.887 / g/L increase in serum albumin, 95% CI 0.839-0.937, p Conclusion The ECS appears to be a significant predictor of MACE in PD patients independently of DM and pre-existing CVD. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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