Exome-Wide Association Analysis of Coronary Artery Disease in the Kingdom of Saudi Arabia Population
| Autor: | Rudaynah A. Alali, Emmanuel Larbi, Khalid A. Al Faraidy, Abdullah Al-Ali, Mohammed S. Al-Madan, Abdullah M. Al-Rubaish, Amein K. Al-Ali, Folkert W. Asselbergs, Bobby P. C. Koeleman, Issa Al Aqaili, Jessica van Setten, Ruben van 't Slot, Flip Mulder, Alhusain J. Alzahrani, Abdullah M. Alshehri, Carolien G.F. de Kovel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Heredity Inheritance Patterns lcsh:Medicine Genome-wide association study Coronary Artery Disease Vascular Medicine Coronary artery disease Risk Factors Medicine and Health Sciences Exome lcsh:Science Non-U.S. Gov't Cause of death Aged 80 and over Genetics education.field_of_study Multidisciplinary Chromosome Biology Mortality rate Research Support Non-U.S. Gov't High-Throughput Nucleotide Sequencing Genomics Middle Aged 3. Good health Genetic Mapping Engineering and Technology Female Research Article Adult Quality Control Genotyping Adolescent Genotype Population Saudi Arabia Variant Genotypes Biology Research and Analysis Methods Research Support Polymorphism Single Nucleotide Chromosomes Young Adult 03 medical and health sciences Age Distribution Quantitative Trait Heritable Industrial Engineering Genome-Wide Association Studies Genetic predisposition medicine Journal Article Humans Genetic Predisposition to Disease Molecular Biology Techniques education Molecular Biology Aged Genetic association Analysis of Variance lcsh:R Biology and Life Sciences Computational Biology Human Genetics Cell Biology Heritability Genome Analysis medicine.disease 030104 developmental biology Genetic Loci lcsh:Q Genome-Wide Association Study Demography |
| Zdroj: | PLoS ONE [E], 11(2). Public Library of Science PLoS One PLoS ONE PLoS ONE, Vol 11, Iss 2, p e0146502 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Coronary Artery Disease (CAD) remains the leading cause of mortality worldwide. Mortality rates associated with CAD have shown an exceptional increase particularly in fast developing economies like the Kingdom of Saudi Arabia (KSA). Over the past twenty years, CAD has become the leading cause of death in KSA and has reached epidemic proportions. This rise is undoubtedly caused by fast urbanization that is associated with a life-style that promotes CAD. However, the question remains whether genetics play a significant role and whether genetic susceptibility is increased in KSA compared to the well-studied Western European populations. Therefore, we performed an Exome-wide association study (EWAS) in 832 patients and 1,076 controls of Saudi Arabian origin to test whether population specific, strong genetic risk factors for CAD exist, or whether the polygenic risk score for known genetic risk factors for CAD, lipids, and Type 2 Diabetes show evidence for an enriched genetic burden. Our results do not show significant associations for a single genetic locus. However, the heritability estimate for CAD for this population was high (h(2) = 0.53, S.E. = 0.1, p = 4e(-12)) and we observed a significant association of the polygenic risk score for CAD that demonstrates that the population of KSA, at least in part, shares the genetic risk associated to CAD in Western populations. |
| Databáze: | OpenAIRE |
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