EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV
| Autor: | O. Kan, S. Iqball, Robert E MacLaren, Robin R. Ali, Kamaljit S. Balaggan, S. E. Barker, Margaret Esapa, Rachael A. Pearson, James W B Bainbridge, Katie Binley, Yanai Duran, Stuart Naylor, Andrew Smith |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Angiogenesis viruses Genetic Vectors Terminal nick end labeling Angiogenesis Inhibitors Apoptosis Capillary Permeability Equine infectious anemia Mice chemistry.chemical_compound Transduction Genetic In vivo In Situ Nick-End Labeling Genetics medicine Animals Fluorescein Angiography Angiostatins Molecular Biology Angiostatin Neovascularization Pathologic biology Lasers Retinal Genetic Therapy Macular degeneration biology.organism_classification medicine.disease Choroidal Neovascularization eye diseases Endostatins Up-Regulation Mice Inbred C57BL chemistry Models Animal Immunology Molecular Medicine Endostatin Infectious Anemia Virus Equine |
| Zdroj: | Gene Therapy. 13:1153-1165 |
| ISSN: | 1476-5462 0969-7128 |
| DOI: | 10.1038/sj.gt.3302769 |
| Popis: | We evaluated the efficacy of equine infectious anaemia virus (EIAV)-based lentiviral vectors encoding endostatin (EIAV.endostatin) or angiostatin (EIAV.angiostatin) in inhibiting angiogenesis and vascular hyperpermeability in the laser-induced model of choroidal neovascularisation (CNV). Equine infectious anaemia virus.endostatin, EIAV.angiostatin or control (EIAV.null) vectors were administered into the subretinal space of C57Bl/6J mice. Two weeks after laser injury CNV areas and the degree of vascular hyperpermeability were measured by image analysis of in vivo fluorescein angiograms. Compared with EIAV.null-injected eyes, EIAV.endostatin resulted in a 59.5% (P |
| Databáze: | OpenAIRE |
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