Influence of Oligodeoxyribonucleotides on the Immune Response of Newborn AKR Mice
| Autor: | Maureen Hechtel, Theodor Dishon, Werner Braun |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Pathology
medicine.medical_specialty Erythrocytes Biology General Biochemistry Genetics and Molecular Biology Serology Hemolysin Proteins Mice Immune system Antigen medicine Animals Mesenteric lymph nodes Mesentery Pancreas Lymph node Nucleotides Hemolysin Metabolism Molecular biology medicine.anatomical_structure Animals Newborn Antibody Formation Lymph Nodes Lymph Spleen |
| Zdroj: | Experimental Biology and Medicine. 119:991-993 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-119-30357 |
| Popis: | SummaryOligodeoxyribonucleotides, administered to newborn AKR mice in conjunction with sheep red blood cells, influence the time of appearance of hemolysin-forming cells in pancreatic and mesenteric lymph nodes. Thus, in comparison with animals that received the antigen only, 5- and 7-day-old animals injected with antigen and oligodeoxyribonucleotides, subsequently showed hemolysin-forming lymph node cells one to 3 days earlier. Such differences were not detected in assays on spleen cell populations and circulating hemolysins. The sequence of first appearance of antibody-producing cells in the organs assayed was spleen→pancreatic lymph nodes→mesenteric lymph nodes, and this sequence was not affected by administration of oligodeoxyribonucleotides. |
| Databáze: | OpenAIRE |
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