Osteoporosis and Endplate Damage Correlation Using a Combined Approach of Hounsfield Unit Values and Total Endplate Scores: A Retrospective Cross-Sectional Study
| Autor: | Weisin Chen, Juan Li, Bo Tian, Chenyang Zhuang, Zixiang Wang, Hong Lin |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cross-sectional study Osteoporosis Intervertebral Disc Degeneration degenerative disc diseases Degenerative disc disease Bone Density Hounsfield scale Humans Medicine Correlation of Data Aged Retrospective Studies Original Research Bone mineral Lumbar Vertebrae business.industry computed tomography General Medicine Odds ratio medicine.disease Magnetic Resonance Imaging Confidence interval Cross-Sectional Studies Clinical Interventions in Aging Quality of Life Female Geriatrics and Gerontology Tomography X-Ray Computed bone mineral density business Nuclear medicine Body mass index |
| Zdroj: | Clinical Interventions in Aging |
| ISSN: | 1178-1998 |
| DOI: | 10.2147/cia.s315213 |
| Popis: | Chenyang Zhuang,1,* Zixiang Wang,1,* Weisin Chen,1 Bo Tian,1 Juan Li,1,2 Hong Lin1,2 1Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, Peopleâs Republic of China; 2Department of Orthopedics, Shanghai Geriatrics Center, Fudan University, Shanghai, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Juan LiDepartment of Orthopedics, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, Peopleâs Republic of ChinaTel/Fax +86 21 6404 1990Email li_juan1983@outlook.comHong LinDepartment of Orthopedics, Shanghai Geriatrics Center, Fudan University, No. 2560 Chunshen Road, Shanghai, 201104, Peopleâs Republic of ChinaEmail lin.hong1@zs-hospital.sh.cnPurpose: Osteoporosis and endplate damage, two primary orthopedic disorders that have adverse effects on the quality of life of older adults, may have some previously unknown relationship. The purpose of this study was to determine the potential association between osteoporosis and endplate damage with two specific imaging scoring systems and analyze the underlying mechanisms.Patients and Methods: A cross-sectional study including 156 patients with degenerative disc disease (DDD) who visited our department in 2018 was performed. Data including age, sex, body mass index, Hounsfield unit (HU) values utilizing computed tomography (CT), and total endplate scores (TEPSs) using magnetic resonance imaging (MRI) of all patients were retrospectively collected and analyzed. The average HU value and TEPS of L1âL4 were used to represent the degrees of bone mineral density (BMD) and endplate damage, respectively. Patients with an HU value < 110 were defined as having osteoporosis and placed in the low-BMD group; otherwise, they were placed in the normal-BMD group. Multivariate logistic regression models were used to determine the independent factors of endplate damage.Results: The TEPSs in the low-BMD group were significantly higher (6.4 ± 1.6 vs 5.0 ± 0.9, p < 0.001) overall and in every segment of L1âL4 (p < 0.01). A significant negative correlation was found between TEPS and HU values (p < 0.001). The HU value (odds ratio [OR] 0.221; 95% confidence interval [CI], 0.148â 0.295, p < 0.001), age (OR 0.047; 95% CI, 0.029â 0.224, p < 0.001), and BMD (OR 3.796; 95% CI, 2.11â 7.382, p < 0.05) were independent factors influencing endplate damage.Conclusion: A significantly positive correlation was observed between osteoporosis and endplate damage, indicating the requirement for a more comprehensive therapeutic regimen for treating patients with DDD complicated with osteoporosis.Keywords: degenerative disc diseases, bone mineral density, computed tomography, magnetic resonance imaging |
| Databáze: | OpenAIRE |
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