Zinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy men
Autor: | T Shuhama, Walter Bloise, Berenice B. Mendonca, José Brandão-Neto, Ana Valeria B. Castro |
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Rok vydání: | 2002 |
Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent Metoclopramide Biology Biochemistry Placebos Inorganic Chemistry Basal (phylogenetics) Dopamine Internal medicine medicine Humans Secretion Dopaminergic Antagonist Brain Prolactin Zinc Endocrinology Dopamine receptor Dopamine Antagonists Molecular Medicine hormones hormone substitutes and hormone antagonists medicine.drug |
Zdroj: | Journal of Trace Elements in Medicine and Biology. 16:69-73 |
ISSN: | 0946-672X |
DOI: | 10.1016/s0946-672x(02)80031-1 |
Popis: | Dopamine (DA) and zinc (Zn++) share common mechanisms in their inhibition of prolactin (PRL) secretion. Both substances are present in the same brain areas, where Zn++ is released together with DA, suggesting a modulatory effect of Zn++ on dopaminergic receptors. The aim of the present study was to evaluate the effect of Zn++ supplementation on basal and PRL secretion stimulated by metoclopramide (MCP), a dopaminergic antagonist. Seven healthy men were evaluated in controlled study, where MCP (5 mg) was given intravenously, before and after 3 months of oral Zn++ (25 mg) administration. Our results indicate that chronic Zn++ administration does not change basal or MCP-stimulated plasma PRL secretion suggesting that, in humans, Zn++ does not interfere on PRL secretion mediated through dopaminergic receptors. |
Databáze: | OpenAIRE |
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