Zinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy men

Autor: T Shuhama, Walter Bloise, Berenice B. Mendonca, José Brandão-Neto, Ana Valeria B. Castro
Rok vydání: 2002
Předmět:
Zdroj: Journal of Trace Elements in Medicine and Biology. 16:69-73
ISSN: 0946-672X
DOI: 10.1016/s0946-672x(02)80031-1
Popis: Dopamine (DA) and zinc (Zn++) share common mechanisms in their inhibition of prolactin (PRL) secretion. Both substances are present in the same brain areas, where Zn++ is released together with DA, suggesting a modulatory effect of Zn++ on dopaminergic receptors. The aim of the present study was to evaluate the effect of Zn++ supplementation on basal and PRL secretion stimulated by metoclopramide (MCP), a dopaminergic antagonist. Seven healthy men were evaluated in controlled study, where MCP (5 mg) was given intravenously, before and after 3 months of oral Zn++ (25 mg) administration. Our results indicate that chronic Zn++ administration does not change basal or MCP-stimulated plasma PRL secretion suggesting that, in humans, Zn++ does not interfere on PRL secretion mediated through dopaminergic receptors.
Databáze: OpenAIRE