Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents
| Autor: | Letícia Lazzarotto, Sandra Denise Camargo Mendes, Valeriano Antonio Corbellini, Daiane Heidrich, Amanda Carvalho Ribeiro, Régis Adriel Zanette, Maria Lúcia Scroferneker, Elissa Kerli Fernandes |
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| Rok vydání: | 2018 |
| Předmět: |
Fonsecaea
Antifungal Agents medicine.disease_cause Microbiology Melanin 03 medical and health sciences chemistry.chemical_compound Ascomycota Species Specificity Phialophora medicine Humans Hydrogen peroxide Phialophora americana 030304 developmental biology Melanins 0303 health sciences Chromoblastomycosis Microbial Viability integumentary system biology 030306 microbiology General Medicine Hydrogen Peroxide Spores Fungal biology.organism_classification medicine.disease Spore Oxidative Stress Thiazoles Infectious Diseases chemistry sense organs Oxidative stress |
| Zdroj: | Medical mycology. 57(2) |
| ISSN: | 1460-2709 |
| Popis: | Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous infection caused by melanized fungal species. We quantified the extractable melanin of 77 strains of CBM agents distributed within five genera. Moreover, resistance to oxidative stress was evaluated in strains exposed or not to the melanin inhibitor tricyclazole. The median percentage of melanin mass extracted from dry fungal mass varied from 0.69 (Rhinocladiella similis) to 3.81 (Phialophora americana). Inhibition of melanin synthesis decreased survival rates to hydrogen peroxide. Together, these data highlight the importance of melanin in CBM agents. |
| Databáze: | OpenAIRE |
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