Measurement of the pulmonary vascular granulocyte pool
| Autor: | A. M. Peters, R. D. Gunasekera, J. M. B. Hughes, W. Y. Ussov, Daphne M. Glass |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Diagnostic Imaging
Pathology medicine.medical_specialty Vena Cava Superior Physiology Heart Ventricles Urology Graft vs Host Disease Inflammation Pulmonary Artery Granulocyte Systemic inflammation Leukocyte Count Superior vena cava Physiology (medical) medicine.artery medicine Humans Radionuclide Imaging Lung Technetium Tc 99m Aggregated Albumin business.industry Osteomyelitis Inflammatory Bowel Diseases medicine.disease medicine.anatomical_structure Ventricle Pulmonary artery medicine.symptom business Blood Flow Velocity Granulocytes Systemic vasculitis |
| Zdroj: | Europe PubMed Central Scopus-Elsevier |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | We have developed a technique for measuring the pulmonary granulocyte pool (PGP) as a fraction of the whole body total blood granulocyte pool (TBGP). The technique “captures” a dose of 99mTc-labeled granulocytes in a region of interest (ROI) over the lung during first pass by integrating an input time-activity curve from an ROI over the pulmonary artery, superior vena cava, or right ventricle. The ratio of the estimated first-pass count rate and the count rate in the same lung ROI after equilibration of the cells between the circulating and pulmonary pools (15–30 min) represents the PGP/TBGP. The technique was validated in eight subjects by using 99mTc-labeled macroaggregated human serum albumin. With corrections for background and injected doses, the ratios of first-pass granulocyte-to-macroaggregated human serum albumin count rates given by the three input ROIs were close to unity [superior vena cava 0.98 +/- 0.079 (SD), right ventricle 1.01 +/- 0.070, and pulmonary artery 0.97 +/- 0.073]. Significant increases in PGP/TBGP were demonstrated in systemic inflammation. Thus, in patients with inflammatory bowel disease, it was 0.22 +/- 0.07 (n = 7) compared with 0.08 +/- 0.01 (n = 5) in control subjects. It was also elevated in patients with systemic vasculitis (0.34 +/- 0.07; n = 5), in transplant recipients (0.33 +/- 0.08; n = 5), and in patients with osteomyelitis (0.15 +/- 0.06; n = 4). We conclude that this is a valid technique for quantifying the PGP that is expanded in several conditions associated with systemic inflammation. |
| Databáze: | OpenAIRE |
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