Recurrent Hypoglycemia in a Case of Congenital Analbuminemia
| Autor: | Monica Campagnoli, Martin Litzel, Lorenzo Minchiotti, Stefan Fischli, Francesca Lugani, Gianluca Caridi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism Recurrent hypoglycemia Albumin Congenital analbuminemia nutritional and metabolic diseases 030209 endocrinology & metabolism Lipid metabolism Case Report 030204 cardiovascular system & hematology Hypoglycemia medicine.disease RC648-665 Gastroenterology Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Moxifloxacin Internal medicine medicine Analbuminemia Risk factor business medicine.drug |
| Zdroj: | Case Reports in Endocrinology, Vol 2020 (2020) Case Reports in Endocrinology |
| ISSN: | 2090-6501 |
| Popis: | In congenital analbuminemia (CAA), mutations in the albumin gene result in a severe deficiency or absence of plasma albumin. Only about 90 cases have been reported to date, but the specific features of glucose and lipid metabolism in congenital analbuminemia have only been studied in a rat model of analbuminemia. We report the case of a female patient hospitalized for a streptococcal skin infection who showed recurrent hypoglycemia. A diagnosis of CAA was confirmed by mutation analysis and by the detection of a single base variation in theALBgene. Hypoglycemia was first documented after a fasting period during acute illness. Recurrent hypoglycemia persisted despite good general condition and normal nutrition during antimicrobial therapy with moxifloxacin. Several contributing factors causing this hypoglycemia can be discussed. Individuals with CAA are prone to adverse drug effects caused by changes in drug-protein binding properties. It is unclear if specific changes of glucose and lipid metabolism in CAA constitute a risk factor for hypoglycemia. |
| Databáze: | OpenAIRE |
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