Triphosgene-amine base promoted chlorination of unactivated aliphatic alcohols

Autor:	Caitlan E. Ayala, Christopher B. Watson, Rendy Kartika, Andrés Villalpando
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Primary (chemistry) Base (chemistry) Triphosgene Organic Chemistry Article chemistry.chemical_compound Stereospecificity chemistry Pyridine Organic chemistry Amine gas treating Alkyl Dichloromethane
Zdroj:	The Journal of organic chemistry. 78(8)
ISSN:	1520-6904
Popis:	Unactivated α-branched primary and secondary aliphatic alcohols have been successfully transformed into their corresponding alkyl chlorides in high yields upon treatment with a mixture of triphosgene and pyridine in dichloromethane at reflux. These mild chlorination conditions are high yielding, stereospecific, and well tolerated by numerous sensitive functionalities. Furthermore, no nuisance waste products are generated in the course of the reactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5aa25ceadbaca2dd7168508660384f6 https://pubmed.ncbi.nlm.nih.gov/23496045 Zobrazit plný text záznamu