Ocular adnexal diffuse large B-cell lymphoma: local disease correlates with better outcomes
| Autor: | V. Menon, Elham Hatef, Simon N. Madge, A Mccormick, I. Patel, L. Irion, Venkatesh C. Prabhakaran, B. Leatherbarrow, Bita Esmaeli, Dinesh Selva, Re Bonshek, S. Honovar |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Systemic disease medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Disease-Free Survival Antibodies Monoclonal Murine-Derived Internal medicine Biomarkers Tumor medicine Humans Immunologic Factors Aged Retrospective Studies Aged 80 and over CD20 Chemotherapy biology business.industry Consecutive case series Middle Aged Prognosis medicine.disease Immunohistochemistry Lymphoma Surgery Radiation therapy Ophthalmology biology.protein Orbital Neoplasms Female Rituximab Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma medicine.drug |
| Zdroj: | Eye. 24:954-961 |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/eye.2009.283 |
| Popis: | To describe the clinical, immunohistochemical and prognostic features, as well as outcomes of a large series of patients with orbital and periorbital diffuse large B-cell lymphoma (DLBCL). This study is a multicentre, retrospective non-comparative consecutive case series. The setting for this study was institutional. A total of 37 consecutive patients identified from the institutions' databases with periorbital and orbital DLBCL were enrolled in the study. A retrospective chart review was used for observation. The main outcome measures were patient demographics, clinical features, imaging, immunohistochemical and histopathological data, treatments administered, and survival. A total of 20 out of 37 cases (54.1%) represented localised periorbital disease (group L), 11 of 37 (29.7%) had systemic disease at presentation with periorbital disease (group S1), and 6 of 37 (16.2%) had previous history of systemic lymphoma (group S2). In all, 28 out of 30 (93.3%) patients were CD20+, 5 of 25 (20%) were CD3+, and 11 of 11 (100%) were CD79a+ (varying denominators reflect the different numbers of patients tested). A total of 25 out of 32 patients (78.1%) received chemotherapy, 14 (43.8%) received rituxmab plus chemotherapy, and 19 (59.3%) received radiotherapy. Nine deaths occurred, one in group L (not lymphoma related), six in group S1, and two in group S2. Five-year Kaplan–Meier survival estimates were 55.9% for all cases, 90.9% for group L, 36.0% for group S1, and 0% for group S2. One-year progression-free survival estimates in groups S1 and S2 combined were 58.3% for patients treated with rituximab and 28.6% for those who were not. To our knowledge, this report represents the largest series of patients with periorbital and orbital DLBCL in the literature. The difference in survival between groups L, S1 and S2 was striking, reflecting the grave prognosis of systemic DLBCL, but conversely the relatively optimistic outlook for patients with localised disease. Rituximab plus chemotherapy may be associated with increased survival. |
| Databáze: | OpenAIRE |
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