Novel diagnostics in renal transplantation
| Autor: | Vijayakrishna K. Gadi, Kimberly Muczynski, Niamh E. Kieran |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology business.industry Microchimerism Review Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry End stage renal disease Transplantation surgical procedures operative Genetics medicine Graft survival Intensive care medicine business Molecular Biology |
| Zdroj: | Chimerism. 1:69-73 |
| ISSN: | 1938-1964 1938-1956 |
| DOI: | 10.4161/chim.1.2.14293 |
| Popis: | Renal transplantation is the treatment of choice for many patients with end stage renal disease. While significant progress has been achieved in short-term outcomes, long-term graft survival has only marginally improved. More than 50% of transplanted kidneys from deceased donors fail within ten years; and from living donors, within 12 years. A lack of clinical tools to accurately monitor the allograft is a major causative factor in this lack of progress. This paper discusses newly available methods used to assess allograft status with emphasis on the role of circulating chimerism in renal transplantation as a diagnostic indicator for rejection and injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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