Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria

Autor: Jacqueline Chevalier, Katarzyna Kieć-Kononowicz, Sandrine Alibert-Franco, Gérard Boyer, Jadwiga Handzlik, Jean-Michel Bolla, Abdallah Mahamoud, Jean-Marie Pagès
Přispěvatelé: Transporteurs membranaires, chimioresistance et drug-design (TMCD2), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Technology and Biotechnology of Drugs, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Alibert, Sandrine
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Lipopolysaccharide
Antibiotics
[CHIM.THER]Chemical Sciences/Medicinal Chemistry
Natural compound
Biochemistry
chemistry.chemical_compound
Structural Biology
antibiotic
Drug Discovery
Selectivity
0303 health sciences
biology
Porin
lipopolysaccharide
gram-negative bacteria
Anti-Bacterial Agents
Membrane permeability
Bacterial efflux pump
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Efflux
Efflux pump inhibitor
Gram-negative bacteria
porin
medicine.drug_class
[CHIM.THER] Chemical Sciences/Medicinal Chemistry
Biophysics
Drug transporter
Microbiology
natural compound
03 medical and health sciences
Gram-Negative Bacteria
Genetics
medicine
Animals
Humans
Molecular Biology
030304 developmental biology
030306 microbiology
MDR bacteria
Cell Membrane
Antibiotic
selectivity
Cell Biology
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
drug transporter
Multiple drug resistance
membrane permeability
chemistry
bacterial efflux pump
chemosensitizer
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Chemosensitizer
[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Bacteria
efflux pump inhibitor
Zdroj: FEBS Letters
FEBS Letters, Wiley, 2011, 585 (11), pp.1682-1690. ⟨10.1016/j.febslet.2011.04.054⟩
ISSN: 0014-5793
1873-3468
DOI: 10.1016/j.febslet.2011.04.054⟩
Popis: International audience; In Gram-negative bacteria, the envelope is a sophisticated barrier protecting the cell against external toxic compounds. Membrane transporters, e.g., porins or efflux pumps, are main filters regulating the internal accumulation of various hydrophilic molecules. Regarding bacterial susceptibility towards antibacterial agents, membrane permeability is part of the early bacterial defense. The bacterium manages the translocation process, influx and efflux, to control the intracellular concentration of various molecules. Antibiotics and biocides are substrates of these mechanisms and the continuing emergence of multidrug resistant isolates is a growing worldwide health concern. Different strategies could be proposed to bypass the bacterial membrane barrier, comprising influx and efflux mechanisms, in order to restore the activity of antibiotics against resistant bacteria.
Databáze: OpenAIRE
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