Text Messaging for Improving Antiretroviral Therapy Adherence: No Effects After 1 Year in a Randomized Controlled Trial Among Adolescents and Young Adults

Autor: Andrew Kambugu, Harsha Thirumurthy, Barbara Mukasa, Jessica E. Haberer, Glenn Wagner, Jill E. Luoto, Sebastian Linnemayr, Haijing Crystal Huang
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Pediatrics
medicine.medical_specialty
Short Message Service
Adolescent
InformationSystems_INFORMATIONINTERFACESANDPRESENTATION(e.g.
HCI)
Anti-HIV Agents
Reminder Systems
MEDLINE
Psychological intervention
AJPH Research
law.invention
Medication Adherence
03 medical and health sciences
Young Adult
0302 clinical medicine
Randomized controlled trial
law
Health care
HIV Seropositivity
Outcome Assessment
Health Care
Trimethoprim
Sulfamethoxazole Drug Combination
Medicine
Humans
Uganda
030212 general & internal medicine
Young adult
Text Messaging
030505 public health
Intention-to-treat analysis
AIDS-Related Opportunistic Infections
business.industry
InformationSystems_INFORMATIONSYSTEMSAPPLICATIONS
Public Health
Environmental and Occupational Health
Confidence interval
Anti-Bacterial Agents
Intention to Treat Analysis
Female
InformationSystems_MISCELLANEOUS
0305 other medical science
business
psychological phenomena and processes
Popis: Objectives. To assess the effectiveness of Short Message Service (SMS) reminder messages on antiretroviral and cotrimoxazole prophylaxis adherence among HIV-positive youths as well as the relative effectiveness of SMS with and without a response option. Methods. Eligible HIV-positive patients aged 15 to 22 years at 2 HIV clinics in Kampala, Uganda, participated in a year-long parallel individual-randomized controlled trial and were assigned in a 1-to-1-to-1 ratio to a weekly SMS message group, weekly SMS message with response option group, or a usual-care control group. Results. We enrolled 332 participants. Electronically measured mean adherence was 67% in the control group, 64% in the 1-way SMS group (95% confidence interval [CI] = 0.77, 1.14), and 61% in the 2-way SMS group (95% CI = 0.75, 1.12) in an intent-to-treat analysis. Results for secondary outcomes and complete-case analysis were similarly statistically insignificant across groups. Conclusions. Despite previous evidence that interventions using SMS reminders can promote antiretroviral therapy adherence, this study shows that they are not always effective in achieving behavior change. More research is needed to find out for whom, and under what conditions, they can be beneficial. Trial registration. ClinicalTrials.gov identifier: NCT00830622.
Databáze: OpenAIRE
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