Rh-Catalyzed tandem C-C/C-N bond formation of quinoxalines with alkynes leading to heterocyclic ammonium salts
| Autor: | Subhasish Roy, Raghunath Bag, Tharmalingam Punniyamurthy, Kangkan Talukdar |
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| Rok vydání: | 2019 |
| Předmět: |
Reaction conditions
Annulation Tandem 010405 organic chemistry Chemistry Organic Chemistry Substrate (chemistry) Bond formation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Functional group Ammonium Physical and Theoretical Chemistry |
| Zdroj: | Organicbiomolecular chemistry. 17(8) |
| ISSN: | 1477-0539 |
| Popis: | An efficient Rh-catalyzed oxidative C–H activation/annulation of 2-arylquinoxalines with internal alkynes is described using Cu(OAc)2·H2O and AgBF4 to afford a diverse variety of substituted quarternary ammonium salts at room temperature. The mechanism of the protocol is established on the basis of isolation of the 5-membered rhodacycle intermediate and kinetic isotope studies. The mild reaction conditions, substrate scope and functional group diversity are the salient practical features. |
| Databáze: | OpenAIRE |
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