Additive Effects of Drinking Habits and a Susceptible Genetic Polymorphism on Cholesterol Efflux Capacity

Autor:	Erika, Matsumoto, Kentaro, Oniki, Ami, Ota-Kontani, Yuri, Seguchi, Yuki, Sakamoto, Tetsuya, Kaneko, Tadashi, Imafuku, Hitoshi, Maeda, Hiroshi, Watanabe, Toru, Maruyama, Yasuhiro, Ogata, Minoru, Yoshida, Mariko, Harada-Shiba, Junji, Saruwatari, Masatsune, Ogura
Rok vydání:	2023
Předmět:	Male Cross-Sectional Studies Polymorphism Genetic Aldehyde Dehydrogenase Mitochondrial Cholesterol HDL Biochemistry (medical) Internal Medicine Humans Aldehyde Dehydrogenase Cardiology and Cardiovascular Medicine
Zdroj:	Journal of Atherosclerosis and Thrombosis. 30:23-38
ISSN:	1880-3873 1340-3478
DOI:	10.5551/jat.63277
Popis:	High levels of high-density lipoprotein cholesterol (HDL-C) are not necessarily effective in preventing atherosclerotic cardiovascular disease, and cholesterol efflux capacity (CEC) has attracted attention regarding HDL functionality. We aimed to elucidate whether drinking habits are associated with CEC levels, while also paying careful attention to confounding factors including serum HDL-C levels, other life style factors, and rs671 (A cross-sectional study was performed in 505 Japanese male subjects who were recruited from a health screening program. Associations of HDL-C and CEC levels with drinking habits and ALDH2 genotypes were examined.The genotype frequencies of ALDH2Our results suggest that heavy drinking habits may tend to decrease CEC levels, and in the ALDH2
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a2c6bf569733abed90751d734d7cd6 https://doi.org/10.5551/jat.63277 Zobrazit plný text záznamu