Supervised Obesity Reduction Trial for AF ablation patients: results from the SORT-AF trial
| Autor: | Nele Gessler, Daniel Steven, Roland Tilz, Boris A Hoffmann, Jens Aberle, Julia Vogler, Peter Wohlmuth, Christian Meyer, Arian Sultan, Stephan Willems, Susanne Scholz, Christian Eickholt, Melanie A Gunawardene, Nils Gosau, Ruken Oezge Akbulak, Jakob Lüker |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Weight reduction Catheter ablation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Recurrence Clinical Research Weight loss Implantable loop recorder Physiology (medical) Internal medicine medicine Clinical endpoint Humans AcademicSubjects/MED00200 Obesity Prospective Studies 030212 general & internal medicine Stroke Aged business.industry Atrial fibrillation Odds ratio Middle Aged medicine.disease Ablation for Atrial Fibrillation Obstructive sleep apnea Editor's Choice Atrial fibrillation burden Treatment Outcome Catheter Ablation Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Europace |
| ISSN: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/euab122 |
| Popis: | Aims Weight management seems to be beneficial for obese atrial fibrillation (AF) patients; however, randomized data are sparse. Thus, this study aimed to investigate the influence of weight reduction on AF ablation outcomes. Methods and results SORT-AF is an investigator-sponsored, prospective, randomized, multicentre, and clinical trial. Patients with symptomatic AF (paroxysmal or persistent) and body mass index (BMI) 30–40 kg/m2 underwent AF ablation and were randomized to either weight-reduction (group 1) or usual care (group 2), after sleep–apnoea–screening and loop recorder (ILR) implantation. The primary endpoint was defined as AF burden between 3 and 12 months after AF ablation. Overall, 133 patients (60 ± 10 years, 57% persistent AF) were randomized to group 1 (n = 67) and group 2 (n = 66), respectively. Complications after AF-ablation were rare (one stroke and no tamponade). The intervention led to a significant reduction of BMI (34.9 ± 2.6–33.4 ± 3.6) in group 1 compared to a stable BMI in group 2 (P Conclusion The SORT-AF study shows that AF ablation is safe and successful in obese patients using continuous monitoring via ILR. Although the primary endpoint of AF burden after ablation did not differ between the two groups, the effects of weight loss and improvement of exercise activity were beneficial for obese patients with persistent AF demonstrating the relevance of life-style management as an important adjunct to AF ablation in this setting. Trial registration number NCT02064114. |
| Databáze: | OpenAIRE |
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