Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa

Autor:	Kazuhiro Tateda, Thilo Köhler, Christian van Delden, Jean-Claude Pechère, Rachel Comte, Keizo Yamaguchi
Rok vydání:	2001
Předmět:	Anti-Bacterial Agents/ pharmacology Azithromycin medicine.disease_cause Azithromycin/ pharmacology Virulence factor Microbiology Bacterial Proteins medicine Pharmacology (medical) Mechanisms of Action: Physiological Effects Lac Operon/drug effects Antibacterial agent ddc:616 Pharmacology biology Pseudomonas aeruginosa/ drug effects Pseudomonas aeruginosa Membrane Transport Proteins DNA-Binding Proteins/drug effects biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Bacterial Proteins/ drug effects Anti-Bacterial Agents DNA-Binding Proteins Quorum sensing Infectious Diseases Lac Operon Pseudomonadales Trans-Activators Autoinducer Trans-Activators/drug effects Bacteria Pseudomonadaceae
Zdroj:	Antimicrobial Agents and Chemotherapy, Vol. 45, No 6 (2001) pp. 1930-1933
ISSN:	0066-4804
Popis:	We report that 2 μg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI . We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a1c0f8064b45e79082a66bc7f5a274 https://pubmed.ncbi.nlm.nih.gov/11353657 Zobrazit plný text záznamu