Current status of breast cancer screening in high-risk women in Japan
Autor: | Seigo Nakamura, Mitsuhiro Tozaki |
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Rok vydání: | 2020 |
Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Breast Neoplasms 03 medical and health sciences Breast cancer screening 0302 clinical medicine Breast cancer Japan Risk Factors medicine Humans Mass Screening Mammography Breast MRI Pharmacology (medical) Radiology Nuclear Medicine and imaging skin and connective tissue diseases Pathological BRCA2 Protein Modalities medicine.diagnostic_test BRCA1 Protein business.industry General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Clinical trial 030104 developmental biology Oncology 030220 oncology & carcinogenesis Family medicine Female Ovarian cancer business |
Zdroj: | Breast Cancer. 28:1181-1187 |
ISSN: | 1880-4233 1340-6868 |
Popis: | Overseas, the importance for breast MRI screening for high-risk groups has been shown. However, the evidence among Japanese population was lacking. Therefore, we collaborated with the "Study on clinical and genetic characterization of hereditary breast and ovarian cancer and improvement in prognosis using genetic information in Japan" group, as part of the Comprehensive Research Project on the Promotion of Cancer Control, Health and Labour Sciences Research, and have been conducting the study entitled, "Study of the usefulness of MRI surveillance of BRCA1/2 mutation carriers" since 2014. In addition, we found that in the Japanese population also, the pathological and imaging characteristics differ between BRCA1 and BRCA2 mutation carriers, like in non-Japanese populations by the several reports. In high-risk females, risk categories such as BRCA1 or BRCA2 mutation carriers are very important. Furthermore, in the future, the optimal surveillance modalities and examination intervals would also vary according to the age, thinness of the breast (constitution), breast density (individual differences on mammography), etc.; this would be "personalized surveillance", and quality-assured MRI examination is of the essence. This review will present clinical trial data of prospective MRI surveillance in Japan, and summarize the current status of breast cancer screening in high-risk Japanese women. |
Databáze: | OpenAIRE |
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