Targeting protein misfolding to protect pancreatic beta-cells in type 2 diabetes
| Autor: | Safia Costes |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose endocrine system Protein Folding Amyloid Type 2 diabetes 03 medical and health sciences Pancreatic beta Cells Diabetes mellitus Insulin-Secreting Cells Drug Discovery medicine Animals Humans Hypoglycemic Agents Molecular Targeted Therapy Proteostasis Deficiencies Pharmacology geography geography.geographical_feature_category business.industry Islet medicine.disease 030104 developmental biology Diabetes Mellitus Type 2 Apoptosis Drug Design Cancer research Protein folding Diffusion of Innovation business Function (biology) Biomarkers Signal Transduction |
| Zdroj: | Current opinion in pharmacology. 43 |
| ISSN: | 1471-4973 |
| Popis: | The islet in type 2 diabetes is characterized by beta-cell dysfunction and deficit, increased beta-cell apoptosis and amyloid deposits that derived from islet amyloid polypeptide (IAPP). In species such as humans that are vulnerable to developing type 2 diabetes, IAPP has the propensity to form toxic oligomers that contribute to beta-cell dysfunction and apoptosis, defining type 2 diabetes as a protein misfolding disorder. In this report, we review mechanisms known to contribute to protein misfolding and formation of toxic oligomers, and the deleterious consequences of these oligomers on beta-cell function and survival. Finally, we will consider approaches to prevent protein misfolding and formation of toxic oligomers as potential novel therapeutic targets for type 2 diabetes and other protein misfolding diseases. |
| Databáze: | OpenAIRE |
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