The impact of clonal diversity and mosaicism on haematopoietic function in Fanconi anaemia
| Autor: | Peter Kurre, Andrew D Hughes |
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| Rok vydání: | 2021 |
| Předmět: |
Genetic enhancement
Context (language use) Disease Biology Somatic evolution in cancer Clonal Evolution medicine Animals Humans Mosaicism Bone marrow failure Disease Management Genetic Variation Cancer Cell Differentiation Genetic Therapy Hematology Hematopoietic Stem Cells medicine.disease Combined Modality Therapy Hematopoiesis Molecular Imaging Haematopoiesis Cell Transformation Neoplastic Fanconi Anemia Gene Expression Regulation Cell Tracking Cytogenetic Analysis Immunology Disease Susceptibility Biomarkers Function (biology) DNA Damage Signal Transduction |
| Zdroj: | British Journal of Haematology. 196:274-287 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.17653 |
| Popis: | Recent advances have facilitated studies of the clonal architecture of the aging haematopoietic system, and provided clues to the mechanisms underlying the origins of hematopoietic malignancy. Much less is known about the clonal composition of haematopoiesis and its impact in bone marrow failure (BMF) disorders, including Fanconi anaemia (FA). Understanding clonality in FA is likely to inform both the marked predisposition to cancer and the rapid erosion of regenerative reserve seen with this disease. This may also hold broader lessons for haematopoietic stem cell biology in other diseases with a clonal restriction. In this review, we focus on the conceptual basis and available tools to study clonality, and highlight insights in somatic mosaicism and malignant evolution in FA in the context of haematopoietic failure and gene therapy. |
| Databáze: | OpenAIRE |
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