Specific inhibition of a calcium dependent activation of brain cyclic AMP phosphodiesterase activity by vinblastine
| Autor: | E. F. Williams, J. S. Law, W. L. West, K. Watanabe |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
chemistry.chemical_element
Calcium Pharmacology Vinblastine Cellular and Molecular Neuroscience In vivo medicine Animals Nucleotide Molecular Biology chemistry.chemical_classification Activator (genetics) Phosphodiesterase Brain Cell Biology In vitro Cyclic AMP phosphodiesterase activity Rats Enzyme Activation chemistry Biochemistry 3' 5'-Cyclic-AMP Phosphodiesterases Molecular Medicine medicine.drug |
| Zdroj: | Experientia. 35(11) |
| ISSN: | 0014-4754 |
| Popis: | Vinblastine selectively inhibits the activation of brain cyclic AMP phosphodiesterase activity by Ca++-protein activator (50% inhibition by 2 x 10(-5) M). This inhibitory effect was reversed by excessive amounts of the activator, whereas large quantities of Ca++ caused only a slight suppression of the vinblastine effect. This result of vinblastine suggests a new site of its action and also suggests the possible role of protein activator, phosphodiesterase proteins or cyclic nucleotides in the previously known effects of vinblastine in vivo and in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|