Interactions of single-wall carbon nanotubes with endothelial cells
| Autor: | Adriana Albini, Alessandro Parodi, Enrico Francheschi, Douglas M. Noonan, Fausto Sessa, Ugo Valbusa, Valentina Mussi, Sara Tegami, M. Rocchia, Agostina Ventura, Giovanna Finzi, Elisa Principi, Rosaria Cammarota, Ilaria Sogno |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Materials science
Endothelium Angiogenesis Biomedical Engineering Morphogenesis Pharmaceutical Science Medicine (miscellaneous) Bioengineering Nanotechnology Carbon nanotube Angiogenesis Endothelium Nanoparticles Nanotubes law.invention law medicine Humans General Materials Science Cells Cultured Nanotubes Nanotubes Carbon Vesicle Endothelial Cells Biological activity In vitro Endocytosis medicine.anatomical_structure Toxicity Biophysics Nanoparticles Molecular Medicine |
| Zdroj: | Nanomedicine : nanotechnology, biology, and medicine. 6(2) |
| ISSN: | 1549-9642 |
| Popis: | Single-wall carbon nanotubes (SWCNTs) could be promising delivery vehicles for cancer therapy. These carriers are generally introduced intravenously, however, little is known of their interactions with endothelial cells, the cells lining vessels and mediating clearance of nanoparticles. Here we show that SWCNTs of 1 to 5 μm in length, both “pristine” and functionalized by oxidation, had limited toxicity for endothelial cells in vitro as determined by growth, migration morphogenesis, and survival assays. Endothelial cells transiently took up SWCNTs, and several lines of data indicated that they were associated with an enhanced acidic vesicle compartment within the endothelial cells. Our findings of SWCNT interactions with endothelial cells suggest these may be optimal vehicles for targeting the vasculature and potential carriers of anti-angiogenic drugs. The implications on their biological activity must be taken into account when considering the use of these nanoparticles for therapeutic delivery of drugs. From the Clinical Editor Interactions of single walled carbon nanotubes (SWCNTs) with endothelial cells following IV administration remains unclear. Functionalized and naive SWCNTs of 1-5 mm in length had limited toxicity to endothelial cells in vitro. Endothelial cells transiently took up SWCNTs and were associated with an enhanced acidic vesicle compartment within the cells. These findings suggest that SWCNTs may be promising vehicles for targeting the vasculature and potential carriers of anti-angiogenic drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect