Estrogen and progestogen therapy in advanced ovarian cancer: Preliminary report
| Autor: | Ralph S. Freedman, Lovell A. Jones, Christopher J. Jolles |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Oncology
Medroxyprogesterone medicine.medical_specialty Nausea medicine.drug_class medicine.medical_treatment Ethinyl Estradiol Internal medicine Progesterone receptor medicine Humans Receptor Ovarian Neoplasms Progestogen business.industry Obstetrics and Gynecology Prognosis Regimen Receptors Estrogen Tumor progression Estrogen Drug Therapy Combination Female medicine.symptom Receptors Progesterone business Hormone |
| Zdroj: | Gynecologic Oncology. 16:352-359 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/0090-8258(83)90162-2 |
| Popis: | Eleven women with advanced ovarian cancer were treated with a sequential and combined hormonal regimen designed to induce and bind tumor progesterone receptors. Two partial responses were seen, and two patients with a recent history of rapid tumor progression achieved disease stabilization. One patient experienced a transient ischemic cerebrovascular episode while on therapy, and a second patient discontinued therapy because of nausea. The regimen was able to induce progesterone receptors in vivo. One patient had no progesterone receptor in a pretreatment tumor biopsy, but did have a high titer of receptors after her first cycle of treatment. |
| Databáze: | OpenAIRE |
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