Radiotherapy for metastases to the mandible in children
| Autor: | Michael R. Wollman, Melvin Deutsch |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Hemangiosarcoma Rectum Sarcoma Ewing Adenocarcinoma Metastasis Neuroblastoma medicine Humans Angiosarcoma Child Retrospective Studies Chemotherapy Spinal Neoplasms business.industry Rectal Neoplasms Liver Neoplasms Palliative Care Infant Radiotherapy Dosage medicine.disease Surgery Pain Intractable Radiation therapy Mandibular Neoplasms medicine.anatomical_structure Otorhinolaryngology El Niño Child Preschool Female Sarcoma Oral Surgery business |
| Zdroj: | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 60(3) |
| ISSN: | 0278-2391 |
| Popis: | Purpose: We present a retrospective review of all children treated since 1979 at our institution with radiotherapy for symptomatic metastases that involve the mandible. Patients and Methods: Nine children were treated with 1 or more courses of radiotherapy for symptomatic metastases that involve the mandible. Six children had a neuroblastoma, 1 had angiosarcoma of the liver, 1 had adenocarcinoma of the rectum, and 1 had peripheral primitive neuroectodermal tumor (Ewing's sarcoma) of the spine. In 3 children, the mandible was the first bone involved by metastases. Seven children were treated with short intensive courses of radiotherapy consisting of 1 to 3 fractions to a total dose of 400 to 1,200 cGy. One child received 2,400 cGy in 6 fractions, and another child received 3,000 cGy in 10 fractions. Three children were treated with second courses of radiotherapy at 1, 2, and 5 months, respectively, from the initial course of radiotherapy. All children had received chemotherapy. Results: All children died of disseminated disease at 5 to 59 months from their initial diagnosis, 5 to 29 months from the detection of metastases to bone, and only 6 days to 17 months (median, 2 months) from the first treatment of metastases to the mandible. Conclusions: The outlook for children with metastases that involve the mandible is very poor, and we recommend short intensive courses of radiotherapy consisting of 1 to 3 treatments to total doses of 400 to 1,200 cGy for palliation of pain. © 2002 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 60:269-271, 2002 |
| Databáze: | OpenAIRE |
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