Probiotics Reduce the Prevalence of Oral Candida in the Elderly—a Randomized Controlled Trial
| Autor: | Riitta Korpela, Heli Yli-Knuuttila, Tuija Poussa, Katja Hatakka, Malcolm Richardson, Aila J. Ahola, Jukka H. Meurman |
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| Rok vydání: | 2007 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Lactobacillus GG Colony Count Microbial Biology Xerostomia Gastroenterology law.invention Microbiology 03 medical and health sciences Probiotic 0302 clinical medicine Primary outcome Double-Blind Method Randomized controlled trial Candidiasis Oral Cheese law Internal medicine medicine Humans Elderly people Probiotic bacteria Saliva General Dentistry Aged Candida Aged 80 and over Probiotics Propionibacterium 030206 dentistry Yeast Lactobacillus 030104 developmental biology Colony count |
| Zdroj: | Journal of Dental Research. 86:125-130 |
| ISSN: | 1544-0591 0022-0345 |
| Popis: | Overgrowth of oral yeast is a common problem among the elderly. Probiotic bacteria are known to inhibit the growth of pathogenic microbes. We tested the hypothesis that cheese containing probiotic bacteria can reduce the prevalence of oral Candida. During this 16-week, randomized, double-blind, placebo-controlled study, 276 elderly people consumed daily 50 g of either probiotic (n = 136) or control cheese (n = 140). The primary outcome measure was the prevalence of a high salivary yeast count (≥ 104 cfu/mL) analyzed by the Dentocult® method. The prevalence decreased in the probiotic group from 30% to 21% (32% reduction), and increased in the control group from 28% to 34%. Probiotic intervention reduced the risk of high yeast counts by 75% (OR = 0.25, 95%CI 0.10–0.65, p = 0.004), and the risk of hyposalivation by 56% (OR = 0.44, 95%CI 0.19–1.01, p = 0.05). Thus, probiotic bacteria can be effective in controlling oral Candida and hyposalivation in the elderly. |
| Databáze: | OpenAIRE |
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