A Biological Insight into the Susceptibility to Influenza Infection in Junior Rats by Comprehensive Analysis of lncRNA Profiles
| Autor: | Hua-Zhong Ying, Wen-Wei Zhou, Wen-Ying Yu, Fen-Sheng Qiu, Hao-Kun Chen, Mei-Ying Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Article Subject
Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley Orthomyxoviridae Infections Downregulation and upregulation microRNA Influenza A virus medicine Animals RNA Messenger Gene Genetics General Immunology and Microbiology Competing endogenous RNA Gene Expression Profiling Interleukin-17 RNA General Medicine Rats Gene expression profiling Disease Models Animal MicroRNAs Medicine RNA Long Noncoding Disease Susceptibility Signal transduction Research Article |
| Zdroj: | BioMed Research International, Vol 2021 (2021) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Long noncoding RNAs (lncRNAs) have been reported to participate in regulating many biological processes, including immune response to influenza A virus (IAV). However, the association between lncRNA expression profiles and influenza infection susceptibility has not been well elucidated. Here, we analyzed the expression profiles of lncRNAs, miRNAs, and mRNAs among IAV-infected adult rat (IAR), normal adult rat (AR), IAV-infected junior rat (IJR), and normal junior rat (JR) by RNA sequencing. Compared with differently expressed lncRNAs (DElncRNAs) between AR and IAR, 24 specific DElncRNAs were found between IJR and JR. Then, based on the fold changes and P value, the top 5 DElncRNAs, including 3 upregulated and 2 downregulated lncRNAs, were chosen to establish a ceRNA network for further disclosing their regulatory mechanisms. To visualize the differentially expressed genes in the ceRNA network, GO and KEGG pathway analysis was performed to further explore their roles in influenza infection of junior rats. The results showed that the downregulated DElncRNA-target genes were mostly enriched in the IL-17 signaling pathway. It indicated that the downregulated lncRNAs conferred the susceptibility of junior rats to IAV via mediating the IL-17 signaling pathway. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text