Factors predictive of prognosis of infantile spasms. A retrospective study in a low-income country
| Autor: | R. Ben Abdelaziz, A. Ben Chehida, Hatem Azzouz, S. Ben Messaoud, Mohamed Slim Abdelmoula, M. Lamouchi, Hela Boudabous, Neji Tebib, D. Ali Mohamed |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Low income Pediatrics medicine.medical_specialty Tunisia Vigabatrin Hospitals University Epilepsy Risk Factors Humans Medicine Practice Patterns Physicians' Poverty Retrospective Studies Psychomotor learning business.industry Infant Retrospective cohort study Prognosis University hospital medicine.disease Hypsarrhythmia Epileptic spasms Pediatrics Perinatology and Child Health Anticonvulsants Female medicine.symptom business Spasms Infantile medicine.drug |
| Zdroj: | Archives de Pédiatrie. 26:1-5 |
| ISSN: | 0929-693X |
| Popis: | Purpose To describe the management of infants with epileptic spasms (ESs) in a low-income country and identify factors predictive of their prognosis. Material and methods We conducted a retrospective study in a university hospital in Tunis, Tunisia, over a period of 10 years. We included infants with recurrent ESs. Results Thirty-eight patients were included. The median age at onset of ESs was 5 months. Typical hypsarrhythmia was found in 21 patients (55%). Brain MRI was done in 32 patients (84%) and metabolic work-up in 34 patients (89%). ESs were categorized as symptomatic in 58% of the patients. Vigabatrin was prescribed as the first-line drug in almost half of the patients. At the last follow-up, 63% of the patients were seizure-free and 82% had a psychomotor delay. The presence of other types of seizures was associated with uncontrolled epilepsy at the last follow-up (P = 0.020). The persistence of spasms after the first-line treatment was associated with abnormal final psychomotor development (P = 0.047). Conclusions Investigation practices and final outcomes of our patients were comparable to data from high-income countries. Treatment practices have been standardized to be in line with international guidelines. |
| Databáze: | OpenAIRE |
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