A novel nairovirus associated with acute febrile illness in Hokkaido, Japan
| Autor: | Masahiro Miyoshi, Ryo Nakao, Yukari Itakura, Yurino Terauchi, Rika Komagome, Chiaki Funaki, Atsushi Nagasaka, Hiroki Yamaguchi, Hirofumi Sawa, Eun-Sil Park, Takuya Ito, Yoshihiro Sakoda, Katsunori Okazaki, Akiko Goto, Ken Maeda, Shunji Edagawa, Kentaro Yoshii, Yasuko Orba, Kango Tatemoto, Hiroaki Kariwa, Keita Matsuno, Keita Mizuma, Asako Shigeno, Fumihiro Kodama, Mariko Sashika, Kimiaki Yamano, Lesley Bell-Sakyi, Masayuki Saijo, Katsuro Hagiwara, Mariko Ishizuka |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Ixodes ricinus Fever Science General Physics and Astronomy Genome Viral Biology Tick Antibodies Viral Article General Biochemistry Genetics and Molecular Biology Virus Serology Leukocyte Count Viral reservoirs Japan Borrelia parasitic diseases medicine Animals Humans Pathogen Phylogeny Nairovirus Multidisciplinary Leukopenia Ixodes Virion General Chemistry Middle Aged biology.organism_classification Virology Viral infection RNA Viral medicine.symptom Viral pathogenesis |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan. Here, Kodama et al. describe the discovery, isolation and characterization of a novel tick-borne orthonairovirus, designated Yezo virus (YEZV), from patients with an acute febrile illness in Japan. Serological testing of wildlife and molecular screening of ticks suggest an endemic circulation of YEZV in Japan. |
| Databáze: | OpenAIRE |
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