Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report
Autor: | Yuki Sakamoto, Souichi Yanamoto, Hiroki Tsuchihashi, Masahiro Umeda, Mitsuko Tokuhisa, Tomofumi Naruse, Kohei Okuyama |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Cetuximab resistance 03 medical and health sciences 0302 clinical medicine Biopsy medicine Epidermal growth factor receptor Cetuximab biology medicine.diagnostic_test business.industry Brain metastasis Cancer Articles medicine.disease Primary tumor 030104 developmental biology Oncology Epithelial-to-mesenchymal transition Oral squamous cell carcinoma Tumor progression 030220 oncology & carcinogenesis biology.protein Lower Gingival Squamous Cell Carcinoma business medicine.drug |
Zdroj: | Oncology Letters |
ISSN: | 1792-1074 |
Popis: | Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment in a 60-year-old man, including findings of an immunohistochemical study. The resected primary tumors, biopsy of the lung metastasis before administration of cetuximab, and brain metastasis specimens mediated by cetuximab were immunohistochemically examined. Histologically, the metastatic brain lesion showed hyperkeratinizing tumor cells with deeply stained irregular nuclei with necrotizing tumor cells, and a decrease in cell density was exhibited in part of the tumor nest. Moreover, the brain lesion was less malignant compared with the primary tumor and metastatic lung lesions. Immunohistochemically, the metastatic brain lesions showed low expression of epidermal growth factor receptor (EGFR) and high expression of N-cadherin compared with the primary tumor and metastatic lung lesions. These results suggest that acquired resistance to cetuximab may be associated with low EGFR expression and increased epithelial-to-mesenchymal transition potential. Oncology Letters, 15(5), pp.7158-7162; 2018 |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |