Nonhereditary enhancement of progeny growth
| Autor: | Marta L. Fiorotto, Leigh-Anne Hill, Ruxandra Draghia-Akli, Amir S. Khan, P. Brandon Malone, Deena Parghi, Robert J. Schwartz, Kathleen K. Cummings, Roy G. Smith |
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| Rok vydání: | 2002 |
| Předmět: |
Pituitary gland
medicine.medical_specialty DNA Complementary Somatotropic cell Offspring Cellular differentiation Gene Expression Gestational Age Growth Biology Growth Hormone-Releasing Hormone Endocrinology Pituitary Gland Anterior Pregnancy Internal medicine Adrenal Glands medicine Animals RNA Messenger Insulin-Like Growth Factor I Rats Wistar Muscle Skeletal Adrenal gland Body Weight Gene Transfer Techniques Cell Differentiation Organ Size medicine.disease Prolactin Rats medicine.anatomical_structure Liver Growth Hormone Body Composition Gestation Female Hormone |
| Zdroj: | Endocrinology. 143(9) |
| ISSN: | 0013-7227 |
| Popis: | The im electroporated injection of a protease-resistant GH-releasing hormone cDNA into rat dams at 16 d gestation resulted in enhanced long-term growth of the F(1) offspring. The offspring were significantly heavier by 2 wk of age, and the difference was sustained to 10 wk of age. Consistent with their augmented growth, the plasma IGF-I concentration of the F(1) progeny was increased significantly. The pituitary gland of the offspring was significantly heavier and contained an increased number of somatotrophs and PRL-secreting cells, which is indicative of modification of cell lineage differentiation. These unique findings demonstrate that enhanced GH-releasing hormone expression in pregnant dams can result in intergenerational growth promotion by altering development of the pituitary gland in the offspring. |
| Databáze: | OpenAIRE |
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