Increased cerebral blood flow in the right anterior cingulate cortex and fronto-orbital cortex during go/no-go task in children with ADHD
| Autor: | Dost Öngür, Cem Calli, Eyüp Sabri Ercan, Sevim Berrin Inci, Burcu Kardaş, Muharrem Burak Baytunca, Melis Ipci, Onur Özyurt, Gül Ünsel Bolat, Blaise de Frederick, Serkan Suren |
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| Přispěvatelé: | Ege Üniversitesi, Işık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümü, Işık University, Faculty of Arts and Sciences, Department of Psychology, İnci İzmir, Sevim Berrin, Tıp Fakültesi, HKÜ, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümü |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Arterial spin labeling Quantitative Biology::Tissues and Organs Physics::Medical Physics Prefrontal Cortex Cognitive neuroscience Neuropsychological Tests Gyrus Cinguli behavioral disciplines and activities Physics::Fluid Dynamics Attention deficit hyperactivity disorder 03 medical and health sciences 0302 clinical medicine children Perfusion fMRI Cortex (anatomy) ASL otorhinolaryngologic diseases medicine Humans ADHD Psychiatry Child Children Cerebral Cortex Brain Mapping Quantitative Biology::Neurons and Cognition business.industry Computer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing) medicine.disease Magnetic Resonance Imaging arterial spin labeling perfusion fMRI 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Cerebral blood flow Right anterior cingulate cortex Attention Deficit Disorder with Hyperactivity Go/no go Cerebrovascular Circulation business Neuroscience 030217 neurology & neurosurgery |
| Popis: | Bolat, Gül Ünsel (Balikesir Author) Objective Arterial spin labeling (ASL) is a relatively new imaging modality in the field of the cognitive neuroscience. In the present study, we aimed to compare the dynamic regional cerebral blood flow alterations of children with ADHD and healthy controls during a neurocognitive task by using event-related ASL scanning. Methods The study comprised of 17 healthy controls and 20 children with ADHD. The study subjects were scanned on 3 Tesla MRI scanner to obtain ASL imaging data. Subjects performed go/no-go task during the ASL image acquisition. The image analyses were performed by FEAT (fMRI Expert Analysis Tool) Version 6. Results The mean age was 10.88 +/- 1.45 and 11 +/- 1.91 for the control and ADHD group, respectively (p = .112). The go/no-go task was utilized during the ASL scanning. The right anterior cingulate cortex (BA32) extending into the frontopolar and orbitofrontal cortices (BA10 and 11) displayed greater activation in ADHD children relative to the control counterparts (p < .001). With a lenient significance threshold, greater activation was revealed in the right-sided frontoparietal regions during the go session, and in the left precuneus during the no-go session. Conclusion These results indicate that children with ADHD needed to over-activate frontopolar cortex, anterior cingulate as well as the dorsal and ventral attention networks to compensate for the attention demanded in a given cognitive task. Ege University |
| Databáze: | OpenAIRE |
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