The association between ethnicity and pre‐eclampsia in Australia: A multicentre retrospective cohort study
| Autor: | H. M. Hudson, Lisa M. Askie, Imad Mahmoud, Sarah J. Lord, Gregory Jenkins, Joel G. Ray, Ziad T. A. Al-Rubaie |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Population Ethnic group Black People Emigrants and Immigrants Lower risk Logistic regression Risk Assessment White People Body Mass Index Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Asian People Pre-Eclampsia Pregnancy Risk Factors Ethnicity Odds Ratio Humans Medicine 030212 general & internal medicine education Retrospective Studies education.field_of_study 030219 obstetrics & reproductive medicine business.industry Australia Obstetrics and Gynecology Retrospective cohort study General Medicine Odds ratio medicine.disease Logistic Models Female business Body mass index Demography |
| Zdroj: | Australian and New Zealand Journal of Obstetrics and Gynaecology. 60:396-404 |
| ISSN: | 1479-828X 0004-8666 |
| DOI: | 10.1111/ajo.13069 |
| Popis: | Background Rates of pre-eclampsia vary between countries and certain ethnic groups. However, there is limited evidence about the impact of ethnicity on risk of pre-eclampsia, beyond established clinical risk factors. Aims To assess the association between ethnicity and pre-eclampsia in Australia's diverse multi-ethnic population. Materials and methods We conducted a retrospective cohort study using the ObstetriX database. We included all women with a birth between January 2011 and December 2014, at Auburn, Blacktown/Mount-Druitt and Westmead Hospitals in the Western Sydney Local Health District. We estimated the pre-eclampsia rate overall, and by maternal ethnic group, defined by country of birth and primary language. We developed multivariable logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CIs) for pre-eclampsia, adjusting for maternal age, body mass index, autoimmune disease, chronic hypertension, chronic renal disease, diabetes mellitus (type 1 or 2), and multiple pregnancy. A secondary analysis was restricted to nulliparous women. Results There were 40 824 women evaluated, including 12 743 nulliparous women. Of these, 1448 (3.5%) developed pre-eclampsia (range: Australian/New Zealand-born English speakers 735/15 422 (4.8%); North-East Asian women 51/4470 (1.1%)). Relative to Australian/New Zealand-born English speakers, immigrants had a lower risk of pre-eclampsia overall (adjusted OR 0.67; 95% CI 0.60-0.75); as did the three largest immigrant groups examined: Southern Asian (0.73; 0.62-0.85), Middle-Eastern/African (0.55; 0.47-0.66) and North-East Asian (0.33; 0.25-0.45) women. Findings were similar for nulliparous women. Conclusions Certain immigrant groups are at lower risk of pre-eclampsia than Australian/New Zealand-born English-speaking women. Understanding why this is so may lead to better screening and preventive strategies in higher-risk women. |
| Databáze: | OpenAIRE |
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