Long-Term Cortisol Concentration in Scalp Hair of Asthmatic Children Using Inhaled Corticosteroids: A Case-Control Study
| Autor: | Dieneke Kramer van Driel, Yolanda B. de Rijke, Gerard Noppe, Erica L T van den Akker, Maaike P Smit, Ed H G van Leer |
|---|---|
| Přispěvatelé: | Internal Medicine, Pediatrics, Clinical Chemistry |
| Rok vydání: | 2017 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System Hydrocortisone Endocrinology Diabetes and Metabolism Pituitary-Adrenal System Inhaled corticosteroids Anti-asthmatic Agent 03 medical and health sciences 0302 clinical medicine Endocrinology Adrenal Cortex Hormones 030225 pediatrics Administration Inhalation Adrenal insufficiency medicine Humans Anti-Asthmatic Agents 030212 general & internal medicine Child Asthma Original Paper Scalp integumentary system business.industry Case-control study medicine.disease Asthmatic children Treatment Outcome medicine.anatomical_structure Case-Control Studies Anesthesia Pediatrics Perinatology and Child Health Female business Hair medicine.drug |
| Zdroj: | Hormone Research in Paediatrics, 88(3-4), 231-236. Karger |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000478526 |
| Popis: | Introduction: Inhaled corticosteroids (ICS) can interfere with the hypothalamic-pituitary-adrenal (HPA) axis and may lead to adrenal insufficiency, resulting in a decrease of cortisol production. Cortisol levels measured in scalp hair provide a marker for long-term cortisol exposure. Data regarding hair cortisol concentration (HCC) in asthmatic children with ICS therapy are scarce. The aim of this study is to compare HCC in asthmatic children under ICS treatment with a healthy control group. Methods: We set up a case-control study measuring the cortisol concentration in scalp hair in asthmatic children (N = 80) treated with ICS and healthy controls (N = 252) aged 4–18 years. Anthropometric characteristics and hair samples from the posterior vertex were obtained. At least 5 mg of the most proximal 3 cm of hair was used for each hair sample. HCC was analyzed by liquid chromatography-tandem mass spectrometry. Results: HCC did not significantly differ between asthmatic children using ICS and healthy controls (p = 0.950) after adjustment for age, gender, height, body mass index, and socioeconomic status. No correlation was found between budesonide dosage and HCC levels (r = –0.031, p = 0.78). Conclusion: There was no evidence of suppression of basal cortisol production, as measured in scalp hair, in asthmatic children using ICS, compared to healthy controls. No conclusions can be drawn on the HPA-axis stress response in these children. |
| Databáze: | OpenAIRE |
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