The intensity of the foreign body response to polyether‐polyurethane implant in diabetic mice is strain‐dependent
Autor: | Mónica Amaral Ferreira, Celso Tarso Rodrigues Viana, Silvia Passos Andrade, Simone Aparecida de Almeida, Laura Alejandra Ariza Orellano, Paula Peixoto Campos, Luciana Xavier Pereira |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Foreign-body giant cell Polyurethanes Biocompatible Materials Pathology and Forensic Medicine Diabetes Mellitus Experimental Mice Fibrosis Diabetes mellitus Internal medicine Medicine Animals Molecular Biology Mice Inbred BALB C business.industry Foreign-Body Reaction Capsule Cell Biology Original Articles Prostheses and Implants medicine.disease Streptozotocin Mast cell Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Endocrinology Apoptosis Implant business Genetic Background medicine.drug |
Zdroj: | Int J Exp Pathol |
Popis: | A number of genetic factors have been linked to the development of diabetes, a condition that often requires implantable devices such as glucose sensors. In normoglycaemic individuals, this procedure induces a foreign body reaction (FBR) that is detrimental to bioimplant functionality. However, the influence of the genetic background on this reaction in diabetes has not been investigated. We examined the components of FBR (capsule thickness, collagen deposition, mast cell and foreign body giant cell number) in subcutaneous implants of polyether polyurethane (SIPP) in streptozotocin (STZ)-induced diabetes in Swiss, C57BL/6 and Balb/c mice. The fasting blood glucose levels before STZ injections were 133.5 ± 5.1 mg/dL, after the treatment increased 68.4% in Swiss mice, 62.4% in C57BL/6 and 30.9% in Balb/c mice. All FBR features were higher in implants of Swiss and C57BL/6 mice compared with those in implants of Balb/c. Likewise, the apoptotic index was higher in implants of diabetic Swiss and C57BL/6 mice whose glycaemic levels were the highest. Our findings show an association between the severity of hyperglycaemic levels and the intensity of the FBR to SIPP. These important strain-related differences in susceptibility to diabetes and the intensity of the FBR must be considered in management using implantable devices in diabetic individuals. |
Databáze: | OpenAIRE |
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