Treatment of spinal osteoporosis in postmenopausal women
| Autor: | B. E. C. Nordin, D. H. Marshall, M. Simpson, R. G. Crilly, A. Horsman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Osteoporosis chemistry.chemical_element Calcium Ethinyl Estradiol Internal medicine medicine Vitamin D and neurology Humans Vitamin D General Environmental Science Aged business.industry Hydroxycholecalciferols General Engineering General Medicine Middle Aged medicine.disease Resorption Menopause Endocrinology medicine.anatomical_structure chemistry General Earth and Planetary Sciences Cortical bone Drug Therapy Combination Female Spinal Diseases Secondary osteoporosis Norethindrone business Hormone Research Article |
| Popis: | Ninety-five postmenopausal women with unequivocably wedged or compressed vertebrae in whom the recognised causes of secondary osteoporosis had been excluded were studied, 41 having no treatment and the rest one or more of six different treatments. The treatment regimens comprised calcium supplements, vitamin D, calcium and vitamin D, ethinyloestradiol or--where oestrogens were contraindicated--norethisterone, 1 alpha-hydroxycholecalciferol (1 alpha-OHD3), or hormones with 1 alpha-OHD3. The seven groups were reasonably comparable in most respects except that the hormone-treated patients were younger and had a higher initial cortical area ratio than the others, and the calcium- and hormone-treated groups had the best initial radio-calcium absorption. The untreated osteoporotic patients lost cortical bone more rapidly than do normal postmenopausal women. Three treatments (calcium, hormones, and 1 alpha OHD3 plus hormones) appear to be useful in modifying the disease, and two treatments (vitamin D and 1 alpha-OHD3) useless or even harmful. Vitamin D and 1 alpha-OHD3 are more safely used in conjunction with oestrogens, which protect bone against resorption, than on their own. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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